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Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?
Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but inc...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805504/ https://www.ncbi.nlm.nih.gov/pubmed/17306014 http://dx.doi.org/10.1186/1475-2875-6-16 |
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author | Vallely, Andrew Vallely, Lisa Changalucha, John Greenwood, Brian Chandramohan, Daniel |
author_facet | Vallely, Andrew Vallely, Lisa Changalucha, John Greenwood, Brian Chandramohan, Daniel |
author_sort | Vallely, Andrew |
collection | PubMed |
description | Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials. |
format | Text |
id | pubmed-1805504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18055042007-02-28 Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? Vallely, Andrew Vallely, Lisa Changalucha, John Greenwood, Brian Chandramohan, Daniel Malar J Review Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials. BioMed Central 2007-02-16 /pmc/articles/PMC1805504/ /pubmed/17306014 http://dx.doi.org/10.1186/1475-2875-6-16 Text en Copyright © 2007 Vallely et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Vallely, Andrew Vallely, Lisa Changalucha, John Greenwood, Brian Chandramohan, Daniel Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? |
title | Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? |
title_full | Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? |
title_fullStr | Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? |
title_full_unstemmed | Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? |
title_short | Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed? |
title_sort | intermittent preventive treatment for malaria in pregnancy in africa: what's new, what's needed? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805504/ https://www.ncbi.nlm.nih.gov/pubmed/17306014 http://dx.doi.org/10.1186/1475-2875-6-16 |
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