Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population

AIMS: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder. METHODS: We investigated three serotonin-related ge...

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Autores principales: Ojima, Kiyomi, Watanabe, Nagaoki, Narita, Naoko, Narita, Masaaki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805776/
https://www.ncbi.nlm.nih.gov/pubmed/17371573
http://dx.doi.org/10.1186/1751-0759-1-3
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author Ojima, Kiyomi
Watanabe, Nagaoki
Narita, Naoko
Narita, Masaaki
author_facet Ojima, Kiyomi
Watanabe, Nagaoki
Narita, Naoko
Narita, Masaaki
author_sort Ojima, Kiyomi
collection PubMed
description AIMS: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder. METHODS: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients. RESULTS: A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by χ(2 )test and Fisher's exact test). CONCLUSION: Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.
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spelling pubmed-18057762007-03-01 Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population Ojima, Kiyomi Watanabe, Nagaoki Narita, Naoko Narita, Masaaki Biopsychosoc Med Short Report AIMS: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder. METHODS: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients. RESULTS: A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by χ(2 )test and Fisher's exact test). CONCLUSION: Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD. BioMed Central 2007-01-10 /pmc/articles/PMC1805776/ /pubmed/17371573 http://dx.doi.org/10.1186/1751-0759-1-3 Text en Copyright © 2007 Ojima et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Ojima, Kiyomi
Watanabe, Nagaoki
Narita, Naoko
Narita, Masaaki
Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
title Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
title_full Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
title_fullStr Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
title_full_unstemmed Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
title_short Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
title_sort temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the japanese population
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805776/
https://www.ncbi.nlm.nih.gov/pubmed/17371573
http://dx.doi.org/10.1186/1751-0759-1-3
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