Cargando…

Aberrant nuclear localization of β-catenin without genetic alterations in β-catenin or Axin genes in esophageal cancer

BACKGROUND: β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation. In this study, we investigated the expression pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kudo, Junzo, Nishiwaki, Tadashi, Haruki, Nobuhiro, Ishiguro, Hideyuki, Shibata, Yasuyuki, Terashita, Yukio, Sugiura, Hironori, Shinoda, Noriyuki, Kimura, Masahiro, Kuwabara, Yoshiyuki, Fujii, Yoshitaka
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808060/ https://www.ncbi.nlm.nih.gov/pubmed/17309796 http://dx.doi.org/10.1186/1477-7819-5-21

Ejemplares similares

Expression of β-catenin and AXIN2 in ameloblastomas
por: Wei, Zhenhui, et al.
Publicado: (2013)

Phase separation of Axin organizes the β-catenin destruction complex
por: Nong, Junxiu, et al.
Publicado: (2021)

Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
por: Thorvaldsen, Tor Espen, et al.
Publicado: (2017)

Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
por: Babcock, Rachel L., et al.
Publicado: (2022)

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta
por: Martino-Echarri, Estefania, et al.
Publicado: (2016)

Isolation and Characterization of Human NBL4, a Gene Involved in the β‐Catenin/Tcf Signaling Pathway
por: Ishiguro, Hideyuki, et al.
Publicado: (2000)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
por: Ji, Lei, et al.
Publicado: (2019)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

UCHL5 controls β-catenin destruction complex function through Axin1 regulation
por: Han, Wonhee, et al.
Publicado: (2022)

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway
por: Wang, Yuting, et al.
Publicado: (2022)

Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear β-catenin expression
por: Koppert, L B, et al.
Publicado: (2004)

NOTCH1 activates the Wnt/β-catenin signaling pathway in colon cancer
por: Ishiguro, Hideyuki, et al.
Publicado: (2017)

Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer
por: Yang, Jiao, et al.
Publicado: (2019)

An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
por: Bernkopf, Dominic B., et al.
Publicado: (2019)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
por: Ranes, Michael, et al.
Publicado: (2021)

Targeting TRIM54/Axin1/β-Catenin Axis Prohibits Proliferation and Metastasis in Hepatocellular Carcinoma
por: Zhu, Jinrong, et al.
Publicado: (2021)

Wnt/Axin1/β-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries
por: Carl, Matthias, et al.
Publicado: (2007)

Forskolin exerts anticancer roles in non-Hodgkin’s lymphomas via regulating Axin/β-catenin signaling pathway
por: Wang, Hailei, et al.
Publicado: (2019)

Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway
por: Chen, Lianqi, et al.
Publicado: (2023)

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
por: Peng, Yin, et al.
Publicado: (2021)

RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
por: Chimge, Nyam-Osor, et al.
Publicado: (2016)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
por: Chen, Hsin-Yi, et al.
Publicado: (2019)

Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation
por: Li, Tie-Mei, et al.
Publicado: (2020)

Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice
por: Xie, Rong, et al.
Publicado: (2022)

TRIM37 promotes gallbladder cancer proliferation by activating the Wnt/β-catenin pathway via ubiquitination of Axin1
por: Xu, Ming, et al.
Publicado: (2023)

Mutations of the β‐Catenin Gene in Endometrial Carcinomas
por: Kobayashi, Kanji, et al.
Publicado: (1999)

CCAAT/enhancer-binding protein-β functions as a negative regulator of Wnt/β-catenin signaling through activation of AXIN1 gene expression
por: Park, Seoyoung, et al.
Publicado: (2018)

Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells
por: Yang, Lian-He, et al.
Publicado: (2010)

SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer
por: Liu, Huidi, et al.
Publicado: (2016)

Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer
por: Cha, Pu-Hyeon, et al.
Publicado: (2016)

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation
por: Ji, Lei, et al.
Publicado: (2017)

Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
por: Babb, Rebecca, et al.
Publicado: (2017)

Imaging features of β-catenin-activated hepatocellular adenoma with weak β-catenin activation: A rare case report
por: Minamiguchi, Kiyoyuki, et al.
Publicado: (2022)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth
por: Miete, Cezanne, et al.
Publicado: (2022)

STAT3 paradoxically stimulates β-catenin expression but inhibits β-catenin function
por: Ibrahem, Salih, et al.
Publicado: (2014)

β‐Catenin Accumulation and Mutation of Exon 3 of the β‐Catenin Gene in Hepatocellular Carcinoma
por: Kondo, Yutaka, et al.
Publicado: (1999)

WNT/β-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma
por: Zhu, Liang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b2psumce29kcv2681d027gjjlu