LRP5 and LRP6 Are Not Required for Protective Antigen–Mediated Internalization or Lethality of Anthrax Lethal Toxin

Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF moieties to the cytosol. Recently, the low-de...

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Detalles Bibliográficos
Autores principales: Young, John J, Bromberg-White, Jennifer L, Zylstra, Cassandra, Church, Joseph T, Boguslawski, Elissa, Resau, James H, Williams, Bart O, Duesbery, Nicholas S
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808072/
https://www.ncbi.nlm.nih.gov/pubmed/17335347
http://dx.doi.org/10.1371/journal.ppat.0030027

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