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Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

BACKGROUND: Data indicates anti-oxidant, anti-inflammatory and pro-cognitive properties of noradrenaline and analyses of post-mortem brain of Alzheimer's disease (AD) patients reveal major neuronal loss in the noradrenergic locus coeruleus (LC), the main source of CNS noradrenaline (NA). The LC...

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Detalles Bibliográficos
Autores principales:	Pugh, Perdita L, Vidgeon-Hart, Martin P, Ashmeade, Tracey, Culbert, Ainsley A, Seymour, Zoe, Perren, Marion J, Joyce, Flora, Bate, Simon T, Babin, Anna, Virley, David J, Richardson, Jill C, Upton, Neil, Sunter, David
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810243/ https://www.ncbi.nlm.nih.gov/pubmed/17324270 http://dx.doi.org/10.1186/1742-2094-4-8

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