Function-Altering SNPs in the Human Multidrug Transporter Gene ABCB1 Identified Using a Saccharomyces-Based Assay

The human ABCB1 (MDR1)-encoded multidrug transporter P-glycoprotein (P-gp) plays a major role in disposition and efficacy of a broad range of drugs including anticancer agents. ABCB1 polymorphisms could therefore determine interindividual variability in resistance to these drugs. To test this hypoth...

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Detalles Bibliográficos
Autores principales: Jeong, Hotcherl, Herskowitz, Ira, Kroetz, Deanna L, Rine, Jasper
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817653/
https://www.ncbi.nlm.nih.gov/pubmed/17352537
http://dx.doi.org/10.1371/journal.pgen.0030039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817653/
https://www.ncbi.nlm.nih.gov/pubmed/17352537
http://dx.doi.org/10.1371/journal.pgen.0030039

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