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Function-Altering SNPs in the Human Multidrug Transporter Gene ABCB1 Identified Using a Saccharomyces-Based Assay
The human ABCB1 (MDR1)-encoded multidrug transporter P-glycoprotein (P-gp) plays a major role in disposition and efficacy of a broad range of drugs including anticancer agents. ABCB1 polymorphisms could therefore determine interindividual variability in resistance to these drugs. To test this hypoth...
Autores principales: | Jeong, Hotcherl, Herskowitz, Ira, Kroetz, Deanna L, Rine, Jasper |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817653/ https://www.ncbi.nlm.nih.gov/pubmed/17352537 http://dx.doi.org/10.1371/journal.pgen.0030039 |
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