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Distinct energetics and closing pathways for DNA polymerase β with 8-oxoG template and different incoming nucleotides
BACKGROUND: 8-Oxoguanine (8-oxoG) is a common oxidative lesion frequently encountered by DNA polymerases such as the repair enzyme DNA polymerase β (pol β). To interpret in atomic and energetic detail how pol β processes 8-oxoG, we apply transition path sampling to delineate closing pathways of pol...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819382/ https://www.ncbi.nlm.nih.gov/pubmed/17313689 http://dx.doi.org/10.1186/1472-6807-7-7 |