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DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion

Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells. AID deaminates deoxycytidine bases in Ig genes, converting them into deoxyuridines. In V...

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Detalles Bibliográficos
Autores principales:	Cook, Adam J. L, Raftery, Joanna M, Lau, K. K. Edwin, Jessup, Andrew, Harris, Reuben S, Takeda, Shunichi, Jolly, Christopher J
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820612/ https://www.ncbi.nlm.nih.gov/pubmed/17355182 http://dx.doi.org/10.1371/journal.pbio.0050080

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