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An unusual cause of granulomatous disease
BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue g...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821032/ https://www.ncbi.nlm.nih.gov/pubmed/17335577 http://dx.doi.org/10.1186/1472-6890-7-1 |
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author | Mclean-Tooke, Andrew PC Aldridge, Catherine Gilmour, Kimberley Higgins, Bernard Hudson, Mark Spickett, Gavin P |
author_facet | Mclean-Tooke, Andrew PC Aldridge, Catherine Gilmour, Kimberley Higgins, Bernard Hudson, Mark Spickett, Gavin P |
author_sort | Mclean-Tooke, Andrew PC |
collection | PubMed |
description | BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation. CASE PRESENTATION: We describe a case of X-linked Chronic granulomatous disease (CGD) diagnosed in an 18-year-old male. He initially presented with granulomatous disease mimicking sarcoidosis and was treated with corticosteroids. He subsequently developed Burkholderia cepacia complex pneumonia and further investigation confirmed a diagnosis of CGD. CONCLUSION: Milder phenotypes of CGD are now being recognised. CGD should be considered in patients of any age with granulomatous diseases, especially if there is a history of recurrent or atypical infection. |
format | Text |
id | pubmed-1821032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18210322007-03-14 An unusual cause of granulomatous disease Mclean-Tooke, Andrew PC Aldridge, Catherine Gilmour, Kimberley Higgins, Bernard Hudson, Mark Spickett, Gavin P BMC Clin Pathol Case Report BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation. CASE PRESENTATION: We describe a case of X-linked Chronic granulomatous disease (CGD) diagnosed in an 18-year-old male. He initially presented with granulomatous disease mimicking sarcoidosis and was treated with corticosteroids. He subsequently developed Burkholderia cepacia complex pneumonia and further investigation confirmed a diagnosis of CGD. CONCLUSION: Milder phenotypes of CGD are now being recognised. CGD should be considered in patients of any age with granulomatous diseases, especially if there is a history of recurrent or atypical infection. BioMed Central 2007-03-02 /pmc/articles/PMC1821032/ /pubmed/17335577 http://dx.doi.org/10.1186/1472-6890-7-1 Text en Copyright © 2007 Mclean-Tooke et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Mclean-Tooke, Andrew PC Aldridge, Catherine Gilmour, Kimberley Higgins, Bernard Hudson, Mark Spickett, Gavin P An unusual cause of granulomatous disease |
title | An unusual cause of granulomatous disease |
title_full | An unusual cause of granulomatous disease |
title_fullStr | An unusual cause of granulomatous disease |
title_full_unstemmed | An unusual cause of granulomatous disease |
title_short | An unusual cause of granulomatous disease |
title_sort | unusual cause of granulomatous disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821032/ https://www.ncbi.nlm.nih.gov/pubmed/17335577 http://dx.doi.org/10.1186/1472-6890-7-1 |
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