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An unusual cause of granulomatous disease

BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue g...

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Autores principales: Mclean-Tooke, Andrew PC, Aldridge, Catherine, Gilmour, Kimberley, Higgins, Bernard, Hudson, Mark, Spickett, Gavin P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821032/
https://www.ncbi.nlm.nih.gov/pubmed/17335577
http://dx.doi.org/10.1186/1472-6890-7-1
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author Mclean-Tooke, Andrew PC
Aldridge, Catherine
Gilmour, Kimberley
Higgins, Bernard
Hudson, Mark
Spickett, Gavin P
author_facet Mclean-Tooke, Andrew PC
Aldridge, Catherine
Gilmour, Kimberley
Higgins, Bernard
Hudson, Mark
Spickett, Gavin P
author_sort Mclean-Tooke, Andrew PC
collection PubMed
description BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation. CASE PRESENTATION: We describe a case of X-linked Chronic granulomatous disease (CGD) diagnosed in an 18-year-old male. He initially presented with granulomatous disease mimicking sarcoidosis and was treated with corticosteroids. He subsequently developed Burkholderia cepacia complex pneumonia and further investigation confirmed a diagnosis of CGD. CONCLUSION: Milder phenotypes of CGD are now being recognised. CGD should be considered in patients of any age with granulomatous diseases, especially if there is a history of recurrent or atypical infection.
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spelling pubmed-18210322007-03-14 An unusual cause of granulomatous disease Mclean-Tooke, Andrew PC Aldridge, Catherine Gilmour, Kimberley Higgins, Bernard Hudson, Mark Spickett, Gavin P BMC Clin Pathol Case Report BACKGROUND: Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation. CASE PRESENTATION: We describe a case of X-linked Chronic granulomatous disease (CGD) diagnosed in an 18-year-old male. He initially presented with granulomatous disease mimicking sarcoidosis and was treated with corticosteroids. He subsequently developed Burkholderia cepacia complex pneumonia and further investigation confirmed a diagnosis of CGD. CONCLUSION: Milder phenotypes of CGD are now being recognised. CGD should be considered in patients of any age with granulomatous diseases, especially if there is a history of recurrent or atypical infection. BioMed Central 2007-03-02 /pmc/articles/PMC1821032/ /pubmed/17335577 http://dx.doi.org/10.1186/1472-6890-7-1 Text en Copyright © 2007 Mclean-Tooke et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mclean-Tooke, Andrew PC
Aldridge, Catherine
Gilmour, Kimberley
Higgins, Bernard
Hudson, Mark
Spickett, Gavin P
An unusual cause of granulomatous disease
title An unusual cause of granulomatous disease
title_full An unusual cause of granulomatous disease
title_fullStr An unusual cause of granulomatous disease
title_full_unstemmed An unusual cause of granulomatous disease
title_short An unusual cause of granulomatous disease
title_sort unusual cause of granulomatous disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821032/
https://www.ncbi.nlm.nih.gov/pubmed/17335577
http://dx.doi.org/10.1186/1472-6890-7-1
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