Cargando…

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans

OBJECTIVES: To assess the effect of variations in GTP cyclohydrolase gene (GCH1) on pain sensitivity in humans. METHODS: Thermal and cold pain sensitivity were evaluated in a cohort of 735 healthy volunteers. Among this cohort, the clinical pain responses of 221 subjects after the surgical removal o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hyungsuk, Dionne, Raymond A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821314/ https://www.ncbi.nlm.nih.gov/pubmed/17343757 http://dx.doi.org/10.1186/1744-8069-3-6

Ejemplares similares

Dopa-Responsive Dystonia in Han Chinese Patients: One Novel Heterozygous Mutation in GTP Cyclohydrolase 1 (GCH1) and Three Known Mutations in TH
por: Yang, Kunfang, et al.
Publicado: (2018)

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I
por: Kümpornsin, Krittikorn, et al.
Publicado: (2014)

Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolo E., et al.
Publicado: (2015)

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
por: Lazarev, Mark, et al.
Publicado: (2008)

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
por: Wu, Hsiang-En, et al.
Publicado: (2016)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
por: Kraft, Vanessa A. N., et al.
Publicado: (2019)

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
por: Ebenhoch, Rebecca, et al.
Publicado: (2020)

Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain
por: Nasser, Arafat, et al.
Publicado: (2013)

Non-Covalent Interaction between Polyubiquitin and GTP Cyclohydrolase 1 Dictates Its Degradation
por: Zhao, Yu, et al.
Publicado: (2012)

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
por: Liu, Yanan, et al.
Publicado: (2017)

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women
por: Wu, Shaohong, et al.
Publicado: (2020)

Identification and Functional Analysis of GTP Cyclohydrolase II in Candida glabrata in Response to Nitrosative Stress
por: Nasuno, Ryo, et al.
Publicado: (2022)

GTP Cyclohydrolase I and Tyrosine Hydroxylase Gene Mutations in Familial and Sporadic Dopa-Responsive Dystonia Patients
por: Cai, Chunyou, et al.
Publicado: (2013)

A Putative Guanosine Triphosphate Cyclohydrolase I Named CaGCH1 Is Involved in Hyphal Branching and Fruiting Development in Cyclocybe aegerita
por: Tao, Nan, et al.
Publicado: (2022)

Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1
por: Kim, Sung Jin, et al.
Publicado: (2009)

Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor
por: Liu, Shiwei, et al.
Publicado: (2023)

GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus
por: Wolkow, Pawel P., et al.
Publicado: (2014)

Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana
por: Osei, Musah, et al.
Publicado: (2018)

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
por: Wang, Shuangxi, et al.
Publicado: (2009)

Overexpression of GTP Cyclohydrolase 1 Feedback Regulatory Protein Is Protective in a Murine Model of Septic Shock
por: Starr, Anna, et al.
Publicado: (2014)

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target
por: Schüssler, Sonja, et al.
Publicado: (2019)

GCH1-polymorphism and pain sensitivity among women with provoked vestibulodynia
por: Heddini, Ulrika, et al.
Publicado: (2012)

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches
por: Hussein, D, et al.
Publicado: (2015)

Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status
por: Asensio Lopez, Maria del Carmen, et al.
Publicado: (2020)

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth
por: Chuaiphichai, Surawee, et al.
Publicado: (2021)

A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast
por: Anam, Khairul, et al.
Publicado: (2020)

Serotonergic system in vivo with [(11)C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients
por: Timmers, Elze R., et al.
Publicado: (2022)

Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo
por: Yin, Ya-Ling, et al.
Publicado: (2022)

In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH(4) Therapeutics
por: Hussein, Dania
Publicado: (2023)

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth
por: Chen, Liye, et al.
Publicado: (2016)

Author Correction: Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status
por: del Carmen Asensio Lopez, Maria, et al.
Publicado: (2020)

Exendin-4 reverses endothelial dysfunction in mice fed a high-cholesterol diet by a GTP cyclohydrolase-1/tetrahydrobiopterin pathway
por: Tang, Zhiqi, et al.
Publicado: (2018)

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance
por: Turkiewicz, Anna, et al.
Publicado: (2020)

Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo
por: Li, Peng, et al.
Publicado: (2016)

GTP-Cyclohydrolase I deficiency presenting as malignant hyperphenylalaninemia, recurrent hyperthermia and progressive neurological dysfunction in a South Asian child – a case report
por: Dayasiri, Kavinda Chandimal, et al.
Publicado: (2019)

Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor
por: Wang, Siyuan, et al.
Publicado: (2023)

Roles of COMT, NPY and GCH1 in acute and chronic pain/stress response
por: Goldman, David
Publicado: (2014)

Different SNP combinations in the GCH1 gene and use of labor analgesia
por: Dabo, Fatimah, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ohihu0l3nj7lr5rff79sp8iq16