Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice

BACKGROUND: Chronic hypoxia induces pulmonary arterial hypertension (PAH). Smooth muscle cell (SMC) proliferation and hypertrophy are important contributors to the remodeling that occurs in chronic hypoxic pulmonary vasculature. We hypothesized that rapamycin (RAPA), a potent cell cycle inhibitor, p...

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Detalles Bibliográficos
Autores principales: Paddenberg, Renate, Stieger, Philipp, von Lilien, Anna-Laura, Faulhammer, Petra, Goldenberg, Anna, Tillmanns, Harald H, Kummer, Wolfgang, Braun-Dullaeus, Ruediger C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821322/
https://www.ncbi.nlm.nih.gov/pubmed/17319968
http://dx.doi.org/10.1186/1465-9921-8-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821322/
https://www.ncbi.nlm.nih.gov/pubmed/17319968
http://dx.doi.org/10.1186/1465-9921-8-15

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