The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumo...

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Autores principales: Maarabouni, Mirna M, Williams, Gwyn T
Formato: Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2006
Materias:
Mini-Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1825760/
https://www.ncbi.nlm.nih.gov/pubmed/17195868
http://dx.doi.org/10.1100/tsw.2006.268
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author Maarabouni, Mirna M
Williams, Gwyn T
author_facet Maarabouni, Mirna M
Williams, Gwyn T
author_sort Maarabouni, Mirna M
collection PubMed
description The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.
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spelling pubmed-18257602007-03-15 The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update Maarabouni, Mirna M Williams, Gwyn T ScientificWorldJournal Mini-Review Article The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene. TheScientificWorldJOURNAL 2006-12-28 /pmc/articles/PMC1825760/ /pubmed/17195868 http://dx.doi.org/10.1100/tsw.2006.268 Text en Copyright © 2006 Mirna M Maarabouni and Gwyn T Williams. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Maarabouni, Mirna M
Williams, Gwyn T
The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
title The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
title_full The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
title_fullStr The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
title_full_unstemmed The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
title_short The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update
title_sort antiapoptotic rbm5/luca-15/h37 gene and its role in apoptosis and human cancer: research update
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1825760/
https://www.ncbi.nlm.nih.gov/pubmed/17195868
http://dx.doi.org/10.1100/tsw.2006.268
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