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Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigeneti...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828059/ https://www.ncbi.nlm.nih.gov/pubmed/17352812 http://dx.doi.org/10.1186/1744-9081-3-14 |
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author | Brummelte, Susanne Teuchert-Noodt, Gertraud |
author_facet | Brummelte, Susanne Teuchert-Noodt, Gertraud |
author_sort | Brummelte, Susanne |
collection | PubMed |
description | Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months. |
format | Text |
id | pubmed-1828059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18280592007-03-16 Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging Brummelte, Susanne Teuchert-Noodt, Gertraud Behav Brain Funct Short Paper Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months. BioMed Central 2007-03-12 /pmc/articles/PMC1828059/ /pubmed/17352812 http://dx.doi.org/10.1186/1744-9081-3-14 Text en Copyright © 2007 Brummelte and Teuchert-Noodt; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Paper Brummelte, Susanne Teuchert-Noodt, Gertraud Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
title | Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
title_full | Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
title_fullStr | Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
title_full_unstemmed | Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
title_short | Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
title_sort | density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging |
topic | Short Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828059/ https://www.ncbi.nlm.nih.gov/pubmed/17352812 http://dx.doi.org/10.1186/1744-9081-3-14 |
work_keys_str_mv | AT brummeltesusanne densityofdopaminergicfibresintheprefrontalcortexofgerbilsissensitivetoaging AT teuchertnoodtgertraud densityofdopaminergicfibresintheprefrontalcortexofgerbilsissensitivetoaging |