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Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigeneti...

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Autores principales: Brummelte, Susanne, Teuchert-Noodt, Gertraud
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828059/
https://www.ncbi.nlm.nih.gov/pubmed/17352812
http://dx.doi.org/10.1186/1744-9081-3-14
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author Brummelte, Susanne
Teuchert-Noodt, Gertraud
author_facet Brummelte, Susanne
Teuchert-Noodt, Gertraud
author_sort Brummelte, Susanne
collection PubMed
description Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months.
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spelling pubmed-18280592007-03-16 Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging Brummelte, Susanne Teuchert-Noodt, Gertraud Behav Brain Funct Short Paper Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months. BioMed Central 2007-03-12 /pmc/articles/PMC1828059/ /pubmed/17352812 http://dx.doi.org/10.1186/1744-9081-3-14 Text en Copyright © 2007 Brummelte and Teuchert-Noodt; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Paper
Brummelte, Susanne
Teuchert-Noodt, Gertraud
Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_full Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_fullStr Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_full_unstemmed Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_short Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
title_sort density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828059/
https://www.ncbi.nlm.nih.gov/pubmed/17352812
http://dx.doi.org/10.1186/1744-9081-3-14
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