A systems biology dynamical model of mammalian G(1) cell cycle progression

The current dogma of G(1) cell-cycle progression relies on growth factor-induced increase of cyclin D:Cdk4/6 complex activity to partially inactivate pRb by phosphorylation and to sequester p27(Kip1)-triggering activation of cyclin E:Cdk2 complexes that further inactivate pRb. pRb oscillates between...

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Detalles Bibliográficos
Autores principales: Haberichter, Thomas, Mädge, Britta, Christopher, Renee A, Yoshioka, Naohisa, Dhiman, Anjali, Miller, Robert, Gendelman, Rina, Aksenov, Sergej V, Khalil, Iya G, Dowdy, Steven F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828753/
https://www.ncbi.nlm.nih.gov/pubmed/17299420
http://dx.doi.org/10.1038/msb4100126

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