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The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
BACKGROUND: Mutations in the PTEN induced putative kinase 1 (PINK1) are implicated in early-onset Parkinson's disease. PINK1 is expressed abundantly in mitochondria rich tissues, such as skeletal muscle, where it plays a critical role determining mitochondrial structural integrity in Drosophila...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831481/ https://www.ncbi.nlm.nih.gov/pubmed/17362513 http://dx.doi.org/10.1186/1471-2164-8-74 |