Haplotype Association between Haptoglobin (Hp2) and Hp Promoter SNP (A-61C) May Explain Previous Controversy of Haptoglobin and Malaria Protection

BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations–despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the c...

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Detalles Bibliográficos
Autores principales: Cox, Sharon E., Doherty, Conor, Atkinson, Sarah H., Nweneka, Chidi V., Fulford, Anthony J.C., Ghattas, Hala, Rockett, Kirk A., Kwiatkowski, Dominic P., Prentice, Andrew M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838521/
https://www.ncbi.nlm.nih.gov/pubmed/17426810
http://dx.doi.org/10.1371/journal.pone.0000362

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