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Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites
In cirrhotic patients, in addition to hepatocytes and Kuppfer cells dysfunction circulatory anatomic shunt and ventilation/perfusion (V(A)/ Q) ratio abnormalities can induce decrease in partial pressure of oxygen in arterial blood (PaO(2)), in oxygen saturation of hemoglobin (SaO(2)) as well as vari...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838824/ https://www.ncbi.nlm.nih.gov/pubmed/17396160 |
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author | Charalabopoulos, Konstantinos Peschos, Dimitrios Zoganas, Leonidas Bablekos, George Golias, Christos Charalabopoulos, Alexander Stagikas, Dimitrios Karakosta, Angi Papathanasopoulos, Athanasios Karachalios, George Batistatou, Anna |
author_facet | Charalabopoulos, Konstantinos Peschos, Dimitrios Zoganas, Leonidas Bablekos, George Golias, Christos Charalabopoulos, Alexander Stagikas, Dimitrios Karakosta, Angi Papathanasopoulos, Athanasios Karachalios, George Batistatou, Anna |
author_sort | Charalabopoulos, Konstantinos |
collection | PubMed |
description | In cirrhotic patients, in addition to hepatocytes and Kuppfer cells dysfunction circulatory anatomic shunt and ventilation/perfusion (V(A)/ Q) ratio abnormalities can induce decrease in partial pressure of oxygen in arterial blood (PaO(2)), in oxygen saturation of hemoglobin (SaO(2)) as well as various acid-base disturbances. We studied 49 cases of liver cirrhosis (LC) with ascites compared to 50 normal controls. Causes were: posthepatic 37 (75.51%), alcoholic 7 (14.24%), cardiac 2 (4.08%), and cryptogenic 3 (6.12%). Complications were: upper gastrointestinal bleeding 24 (48.97), hepatic encephalopathy 20 (40.81%), gastritis 28 (57.14%), hepatoma 5 (10.2%), renal hepatic syndrome 2 (4.01%), HbsAg (+) 24 (48.97%), and hepatic pleural effusions 7 (14.28%). Average PaO(2) and SaO(2) were 75.2 mmHg and 94.5 mmHg, respectively, compared to 94.2 mmHg and 97.1 mmHg of the control group, respectively (p value in both PaO(2) and SaO(2 )was p<0.01). Respiratory alkalosis, metabolic alkalosis, metabolic acidosis, respiratory acidosis and metabolic acidosis with respiratory alkalosis were acid-base disturbances observed. In conclusion, portopulmonary shunt, intrapulmonary arteriovenous shunt and V(A)/Q inequality can induce a decrease in PaO(2) and SaO(2) as well as various acid-base disturbances. As a result, pulmonary resistance is impaired and patients more likely succumb to infections and adult respiratory distress syndrome. |
format | Text |
id | pubmed-1838824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-18388242007-03-29 Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites Charalabopoulos, Konstantinos Peschos, Dimitrios Zoganas, Leonidas Bablekos, George Golias, Christos Charalabopoulos, Alexander Stagikas, Dimitrios Karakosta, Angi Papathanasopoulos, Athanasios Karachalios, George Batistatou, Anna Int J Med Sci Research Paper In cirrhotic patients, in addition to hepatocytes and Kuppfer cells dysfunction circulatory anatomic shunt and ventilation/perfusion (V(A)/ Q) ratio abnormalities can induce decrease in partial pressure of oxygen in arterial blood (PaO(2)), in oxygen saturation of hemoglobin (SaO(2)) as well as various acid-base disturbances. We studied 49 cases of liver cirrhosis (LC) with ascites compared to 50 normal controls. Causes were: posthepatic 37 (75.51%), alcoholic 7 (14.24%), cardiac 2 (4.08%), and cryptogenic 3 (6.12%). Complications were: upper gastrointestinal bleeding 24 (48.97), hepatic encephalopathy 20 (40.81%), gastritis 28 (57.14%), hepatoma 5 (10.2%), renal hepatic syndrome 2 (4.01%), HbsAg (+) 24 (48.97%), and hepatic pleural effusions 7 (14.28%). Average PaO(2) and SaO(2) were 75.2 mmHg and 94.5 mmHg, respectively, compared to 94.2 mmHg and 97.1 mmHg of the control group, respectively (p value in both PaO(2) and SaO(2 )was p<0.01). Respiratory alkalosis, metabolic alkalosis, metabolic acidosis, respiratory acidosis and metabolic acidosis with respiratory alkalosis were acid-base disturbances observed. In conclusion, portopulmonary shunt, intrapulmonary arteriovenous shunt and V(A)/Q inequality can induce a decrease in PaO(2) and SaO(2) as well as various acid-base disturbances. As a result, pulmonary resistance is impaired and patients more likely succumb to infections and adult respiratory distress syndrome. Ivyspring International Publisher 2007-03-06 /pmc/articles/PMC1838824/ /pubmed/17396160 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Charalabopoulos, Konstantinos Peschos, Dimitrios Zoganas, Leonidas Bablekos, George Golias, Christos Charalabopoulos, Alexander Stagikas, Dimitrios Karakosta, Angi Papathanasopoulos, Athanasios Karachalios, George Batistatou, Anna Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites |
title | Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites |
title_full | Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites |
title_fullStr | Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites |
title_full_unstemmed | Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites |
title_short | Alterations in Arterial Blood Parameters in Patients with Liver Cirrhosis and Ascites |
title_sort | alterations in arterial blood parameters in patients with liver cirrhosis and ascites |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838824/ https://www.ncbi.nlm.nih.gov/pubmed/17396160 |
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