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The role of the purinergic P2X(7 )receptor in inflammation

The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its dama...

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Detalles Bibliográficos
Autores principales: Lister, Martin F, Sharkey, John, Sawatzky, Deborah A, Hodgkiss, Joseph P, Davidson, Donald J, Rossi, Adriano G, Finlayson, Keith
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838907/
https://www.ncbi.nlm.nih.gov/pubmed/17367517
http://dx.doi.org/10.1186/1476-9255-4-5
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author Lister, Martin F
Sharkey, John
Sawatzky, Deborah A
Hodgkiss, Joseph P
Davidson, Donald J
Rossi, Adriano G
Finlayson, Keith
author_facet Lister, Martin F
Sharkey, John
Sawatzky, Deborah A
Hodgkiss, Joseph P
Davidson, Donald J
Rossi, Adriano G
Finlayson, Keith
author_sort Lister, Martin F
collection PubMed
description The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X(7 )receptor (P2X(7)R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6. Moreover, as P2X(7)R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X(7)R in inflammation, immunity and its potential role in disease will be reviewed and discussed.
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spelling pubmed-18389072007-03-29 The role of the purinergic P2X(7 )receptor in inflammation Lister, Martin F Sharkey, John Sawatzky, Deborah A Hodgkiss, Joseph P Davidson, Donald J Rossi, Adriano G Finlayson, Keith J Inflamm (Lond) Review The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X(7 )receptor (P2X(7)R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6. Moreover, as P2X(7)R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X(7)R in inflammation, immunity and its potential role in disease will be reviewed and discussed. BioMed Central 2007-03-16 /pmc/articles/PMC1838907/ /pubmed/17367517 http://dx.doi.org/10.1186/1476-9255-4-5 Text en Copyright © 2007 Lister et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lister, Martin F
Sharkey, John
Sawatzky, Deborah A
Hodgkiss, Joseph P
Davidson, Donald J
Rossi, Adriano G
Finlayson, Keith
The role of the purinergic P2X(7 )receptor in inflammation
title The role of the purinergic P2X(7 )receptor in inflammation
title_full The role of the purinergic P2X(7 )receptor in inflammation
title_fullStr The role of the purinergic P2X(7 )receptor in inflammation
title_full_unstemmed The role of the purinergic P2X(7 )receptor in inflammation
title_short The role of the purinergic P2X(7 )receptor in inflammation
title_sort role of the purinergic p2x(7 )receptor in inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838907/
https://www.ncbi.nlm.nih.gov/pubmed/17367517
http://dx.doi.org/10.1186/1476-9255-4-5
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