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Whole genome molecular phylogeny of large dsDNA viruses using composition vector method
BACKGROUND: One important mechanism by which large DNA viruses increase their genome size is the addition of modules acquired from other viruses, host genomes or gene duplications. Phylogenetic analysis of large DNA viruses, especially using methods based on alignment, is often difficult due to the...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839080/ https://www.ncbi.nlm.nih.gov/pubmed/17359548 http://dx.doi.org/10.1186/1471-2148-7-41 |
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author | Gao, Lei Qi, Ji |
author_facet | Gao, Lei Qi, Ji |
author_sort | Gao, Lei |
collection | PubMed |
description | BACKGROUND: One important mechanism by which large DNA viruses increase their genome size is the addition of modules acquired from other viruses, host genomes or gene duplications. Phylogenetic analysis of large DNA viruses, especially using methods based on alignment, is often difficult due to the presence of horizontal gene transfer events. The recent composition vector approach, not sensitive to such events, is applied here to reconstruct the phylogeny of 124 large DNA viruses. RESULTS: The results are mostly consistent with the biologist's systematics with only a few outliers and can also provide some information for those unclassified viruses and cladistic relationships of several families. CONCLUSION: With composition vector approach we obtained the phylogenetic tree of large DNA viruses, which not only give results comparable to biologist's systematics but also provide a new way for recovering the phylogeny of viruses. |
format | Text |
id | pubmed-1839080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18390802007-03-30 Whole genome molecular phylogeny of large dsDNA viruses using composition vector method Gao, Lei Qi, Ji BMC Evol Biol Research Article BACKGROUND: One important mechanism by which large DNA viruses increase their genome size is the addition of modules acquired from other viruses, host genomes or gene duplications. Phylogenetic analysis of large DNA viruses, especially using methods based on alignment, is often difficult due to the presence of horizontal gene transfer events. The recent composition vector approach, not sensitive to such events, is applied here to reconstruct the phylogeny of 124 large DNA viruses. RESULTS: The results are mostly consistent with the biologist's systematics with only a few outliers and can also provide some information for those unclassified viruses and cladistic relationships of several families. CONCLUSION: With composition vector approach we obtained the phylogenetic tree of large DNA viruses, which not only give results comparable to biologist's systematics but also provide a new way for recovering the phylogeny of viruses. BioMed Central 2007-03-15 /pmc/articles/PMC1839080/ /pubmed/17359548 http://dx.doi.org/10.1186/1471-2148-7-41 Text en Copyright © 2007 Gao and Qi; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gao, Lei Qi, Ji Whole genome molecular phylogeny of large dsDNA viruses using composition vector method |
title | Whole genome molecular phylogeny of large dsDNA viruses using composition vector method |
title_full | Whole genome molecular phylogeny of large dsDNA viruses using composition vector method |
title_fullStr | Whole genome molecular phylogeny of large dsDNA viruses using composition vector method |
title_full_unstemmed | Whole genome molecular phylogeny of large dsDNA viruses using composition vector method |
title_short | Whole genome molecular phylogeny of large dsDNA viruses using composition vector method |
title_sort | whole genome molecular phylogeny of large dsdna viruses using composition vector method |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839080/ https://www.ncbi.nlm.nih.gov/pubmed/17359548 http://dx.doi.org/10.1186/1471-2148-7-41 |
work_keys_str_mv | AT gaolei wholegenomemolecularphylogenyoflargedsdnavirusesusingcompositionvectormethod AT qiji wholegenomemolecularphylogenyoflargedsdnavirusesusingcompositionvectormethod |