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Conserved aspartic acid 233 and alanine 231 are not required for poliovirus polymerase function in replicons
Nucleic acid polymerases have similar structures and motifs. The function of an aspartic acid (conserved in all classes of nucleic acid polymerases) in motif A remains poorly understood in RNA-dependent RNA polymerases. We mutated this residue to alanine in a poliovirus replicon. The resulting mutan...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839082/ https://www.ncbi.nlm.nih.gov/pubmed/17352827 http://dx.doi.org/10.1186/1743-422X-4-28 |