Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

BACKGROUND: T cells in the thymus undergo opposing positive and negative selection processes so that the only T cells entering circulation are those bearing a T cell receptor (TCR) with a low affinity for self. The mechanism differentiating negative from positive selection is poorly understood, desp...

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Detalles Bibliográficos
Autores principales: Liston, Adrian, Hardy, Kristine, Pittelkow, Yvonne, Wilson, Susan R, Makaroff, Lydia E, Fahrer, Aude M, Goodnow, Christopher C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839132/
https://www.ncbi.nlm.nih.gov/pubmed/17239257
http://dx.doi.org/10.1186/gb-2007-8-1-r12

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