Cargando…
An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
BACKGROUND: The ubiquitin-proteasome system is responsible for homeostatic degradation of intact protein substrates as well as the elimination of damaged or misfolded proteins that might otherwise aggregate. During ageing there is a decline in proteasome activity and an increase in aggregated protei...
Autores principales: | Proctor, Carole J, Tsirigotis, Maria, Gray, Douglas A |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847462/ https://www.ncbi.nlm.nih.gov/pubmed/17408507 http://dx.doi.org/10.1186/1752-0509-1-17 |
Ejemplares similares
-
Copper homeostasis and the ubiquitin proteasome system
por: Zhang, Bichao, et al.
Publicado: (2023) -
Coupling histone homeostasis to centromere integrity via the ubiquitin-proteasome system
por: Takayama, Yuko, et al.
Publicado: (2010) -
Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome
por: Sun, Lianhui, et al.
Publicado: (2016) -
Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila
por: Ukita, Yumiko, et al.
Publicado: (2022) -
Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
por: Brun, Jan, et al.
Publicado: (2009)