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Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E(2 )from human articular chondrocytes

BACKGROUND: Sphingosine-1-phosphate (S1P), a downstream metabolite of ceramide, induces various bioactivities via two distinct pathways: as an intracellular second messenger or through receptor activation. The receptor for S1P (S1PR) is the family of Endothelial differentiation, sphingolipid G-prote...

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Detalles Bibliográficos
Autores principales:	Masuko, Kayo, Murata, Minako, Nakamura, Hiroshi, Yudoh, Kazuo, Nishioka, Kusuki, Kato, Tomohiro
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847513/ https://www.ncbi.nlm.nih.gov/pubmed/17374154 http://dx.doi.org/10.1186/1471-2474-8-29

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