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Validation of a guideline-based composite outcome assessment tool for asthma control

BACKGROUND: A global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma. METHODS: We used data from 3416 patients rand...

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Autores principales: Spencer, Sally, Mayer, Bhabita, Bendall, Kate L, Bateman, Eric D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847816/
https://www.ncbi.nlm.nih.gov/pubmed/17376233
http://dx.doi.org/10.1186/1465-9921-8-26
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author Spencer, Sally
Mayer, Bhabita
Bendall, Kate L
Bateman, Eric D
author_facet Spencer, Sally
Mayer, Bhabita
Bendall, Kate L
Bateman, Eric D
author_sort Spencer, Sally
collection PubMed
description BACKGROUND: A global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma. METHODS: We used data from 3416 patients randomised and treated in the multi-centre Gaining Optimal Asthma controL (GOAL) study. The criteria comprising the asthma control measures were based on Global Initiative for Asthma/National Institutes of Health guidelines. This validation study examined the measurement properties of the asthma control measures using data from run-in, baseline, 12 and 52 weeks. Forced expiratory volume in 1 second (FEV(1)) and the Asthma Quality of Life Questionnaire (AQLQ) were used as the reference criteria in the validation analysis. RESULTS: Both measures had good discriminative ability showing significant differences in FEV(1 )and AQLQ scores between control classification both cross-sectionally and longitudinally (p < 0.001). Overall both of the composite measures accounted for more of the variance in FEV(1 )after 52 weeks than the individual components of each asthma control measure. Both of the reference criteria were independently related to each asthma control measure (p < 0.0001). The measures also had good predictive validity showing significant differences in FEV(1 )and AQLQ scores at 52 weeks by control classification at 12 weeks (p < 0.0001). CONCLUSION: The guideline-based composite asthma control measures of WC asthma and TC asthma have good psychometric properties and are both valid functional indices of disease control in asthma.
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spelling pubmed-18478162007-04-06 Validation of a guideline-based composite outcome assessment tool for asthma control Spencer, Sally Mayer, Bhabita Bendall, Kate L Bateman, Eric D Respir Res Research BACKGROUND: A global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma. METHODS: We used data from 3416 patients randomised and treated in the multi-centre Gaining Optimal Asthma controL (GOAL) study. The criteria comprising the asthma control measures were based on Global Initiative for Asthma/National Institutes of Health guidelines. This validation study examined the measurement properties of the asthma control measures using data from run-in, baseline, 12 and 52 weeks. Forced expiratory volume in 1 second (FEV(1)) and the Asthma Quality of Life Questionnaire (AQLQ) were used as the reference criteria in the validation analysis. RESULTS: Both measures had good discriminative ability showing significant differences in FEV(1 )and AQLQ scores between control classification both cross-sectionally and longitudinally (p < 0.001). Overall both of the composite measures accounted for more of the variance in FEV(1 )after 52 weeks than the individual components of each asthma control measure. Both of the reference criteria were independently related to each asthma control measure (p < 0.0001). The measures also had good predictive validity showing significant differences in FEV(1 )and AQLQ scores at 52 weeks by control classification at 12 weeks (p < 0.0001). CONCLUSION: The guideline-based composite asthma control measures of WC asthma and TC asthma have good psychometric properties and are both valid functional indices of disease control in asthma. BioMed Central 2007 2007-03-21 /pmc/articles/PMC1847816/ /pubmed/17376233 http://dx.doi.org/10.1186/1465-9921-8-26 Text en Copyright © 2007 Spencer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Spencer, Sally
Mayer, Bhabita
Bendall, Kate L
Bateman, Eric D
Validation of a guideline-based composite outcome assessment tool for asthma control
title Validation of a guideline-based composite outcome assessment tool for asthma control
title_full Validation of a guideline-based composite outcome assessment tool for asthma control
title_fullStr Validation of a guideline-based composite outcome assessment tool for asthma control
title_full_unstemmed Validation of a guideline-based composite outcome assessment tool for asthma control
title_short Validation of a guideline-based composite outcome assessment tool for asthma control
title_sort validation of a guideline-based composite outcome assessment tool for asthma control
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847816/
https://www.ncbi.nlm.nih.gov/pubmed/17376233
http://dx.doi.org/10.1186/1465-9921-8-26
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