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Involvement of α(6)β(4 )integrin in the mechanisms that regulate breast cancer progression
Integrin α(6)β(4 )is mostly expressed in epithelial tissues and endothelial and Schwann cells. Expression of α(6)β(4 )is increased in many epithelial tumours, implicating its involvement in tumour malignancy. Moreover, this integrin activates several key signalling molecules in carcinoma cells, but...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851390/ https://www.ncbi.nlm.nih.gov/pubmed/17319974 http://dx.doi.org/10.1186/bcr1651 |
| Sumario: | Integrin α(6)β(4 )is mostly expressed in epithelial tissues and endothelial and Schwann cells. Expression of α(6)β(4 )is increased in many epithelial tumours, implicating its involvement in tumour malignancy. Moreover, this integrin activates several key signalling molecules in carcinoma cells, but its ability to activate the phosphatidylinositol 3-kinase/Akt pathway is among the mechanisms by which α(6)β(4 )integrin regulates tumour behaviour. In this review we discuss the biological and clinical features of α(6)β(4 )integrin that allow it to promote tumour survival and progression of mammary tumours. |
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