Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma

BACKGROUND: The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conventional small-molecule screening. Des...

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Detalles Bibliográficos
Autores principales: Stegmaier, Kimberly, Wong, Jenny S, Ross, Kenneth N, Chow, Kwan T, Peck, David, Wright, Renee D, Lessnick, Stephen L, Kung, Andrew L, Golub, Todd R
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851624/
https://www.ncbi.nlm.nih.gov/pubmed/17425403
http://dx.doi.org/10.1371/journal.pmed.0040122

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