Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens

BACKGROUND: Natural antibodies directed at carbohydrates reject porcine xenografts. They are initially expressed in germline configuration and are encoded by a small number of structurally-related germline progenitors. The transplantation of genetically-modified pig organs prevents hyperacute reject...

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Detalles Bibliográficos
Autores principales: Kearns-Jonker, Mary, Barteneva, Natasha, Mencel, Robert, Hussain, Namath, Shulkin, Irina, Xu, Alan, Yew, Margaret, Cramer, Donald V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851715/
https://www.ncbi.nlm.nih.gov/pubmed/17352819
http://dx.doi.org/10.1186/1471-2172-8-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851715/
https://www.ncbi.nlm.nih.gov/pubmed/17352819
http://dx.doi.org/10.1186/1471-2172-8-3

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