Safety and Reactogenicity of an MSP-1 Malaria Vaccine Candidate: A Randomized Phase Ib Dose-Escalation Trial in Kenyan Children

OBJECTIVE: Our aim was to evaluate the safety, reactogenicity, and immunogenicity of an investigational malaria vaccine. DESIGN: This was an age-stratified phase Ib, double-blind, randomized, controlled, dose-escalation trial. Children were recruited into one of three cohorts (dosage groups) and ran...

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Detalles Bibliográficos
Autores principales: Withers, Mark R, McKinney, Denise, Ogutu, Bernhards R, Waitumbi, John N, Milman, Jessica B, Apollo, Odika J, Allen, Otieno G, Tucker, Kathryn, Soisson, Lorraine A, Diggs, Carter, Leach, Amanda, Wittes, Janet, Dubovsky, Filip, Stewart, V. Ann, Remich, Shon A, Cohen, Joe, Ballou, W. Ripley, Holland, Carolyn A, Lyon, Jeffrey A, Angov, Evelina, Stoute, José A, Martin, Samuel K, Heppner, D. Gray
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851726/
https://www.ncbi.nlm.nih.gov/pubmed/17124529
http://dx.doi.org/10.1371/journal.pctr.0010032

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