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Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies
We examine here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler’s encephalomyelitis virus, and Coxsackievirus B3] in mice with autoantibodies to a central nervous system (CNS)-specific antigen, myelin oligodendrocyte glycoprotein, that usually develop no clinical dis...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Society for Investigative Pathology
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851853/ https://www.ncbi.nlm.nih.gov/pubmed/17255324 http://dx.doi.org/10.2353/ajpath.2007.060893 |
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author | Burrer, Renaud Buchmeier, Michael J. Wolfe, Tom Ting, Joey P.C. Feuer, Ralph Iglesias, Antonio von Herrath, Matthias G. |
author_facet | Burrer, Renaud Buchmeier, Michael J. Wolfe, Tom Ting, Joey P.C. Feuer, Ralph Iglesias, Antonio von Herrath, Matthias G. |
author_sort | Burrer, Renaud |
collection | PubMed |
description | We examine here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler’s encephalomyelitis virus, and Coxsackievirus B3] in mice with autoantibodies to a central nervous system (CNS)-specific antigen, myelin oligodendrocyte glycoprotein, that usually develop no clinical disease. Morbidity and mortality of the acute viral CNS disease was augmented by the presence of the autoantibodies in all three viral infections. Transfer of serum containing the autoantibodies at the time of infection with MHV was sufficient to reproduce the exacerbated disease. The presence of the autoantibodies was found to result in increased infiltration of mononuclear cells into the brain. Early demyelination was severely augmented in brains and spinal cords of MHV-infected mice with CNS-specific autoantibodies. The antibody-mediated exacerbation was shown to be independent of the complement system but to require expression of Fc receptors, because it was observed in C′-3-deficient but not in Fc receptor-deficient mice. Our study illustrates the possibility that infections can lead to much more profound immunopathology in the presence of an otherwise latent autoimmune condition. |
format | Text |
id | pubmed-1851853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | American Society for Investigative Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-18518532007-08-01 Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies Burrer, Renaud Buchmeier, Michael J. Wolfe, Tom Ting, Joey P.C. Feuer, Ralph Iglesias, Antonio von Herrath, Matthias G. Am J Pathol Regular Articles We examine here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler’s encephalomyelitis virus, and Coxsackievirus B3] in mice with autoantibodies to a central nervous system (CNS)-specific antigen, myelin oligodendrocyte glycoprotein, that usually develop no clinical disease. Morbidity and mortality of the acute viral CNS disease was augmented by the presence of the autoantibodies in all three viral infections. Transfer of serum containing the autoantibodies at the time of infection with MHV was sufficient to reproduce the exacerbated disease. The presence of the autoantibodies was found to result in increased infiltration of mononuclear cells into the brain. Early demyelination was severely augmented in brains and spinal cords of MHV-infected mice with CNS-specific autoantibodies. The antibody-mediated exacerbation was shown to be independent of the complement system but to require expression of Fc receptors, because it was observed in C′-3-deficient but not in Fc receptor-deficient mice. Our study illustrates the possibility that infections can lead to much more profound immunopathology in the presence of an otherwise latent autoimmune condition. American Society for Investigative Pathology 2007-02 /pmc/articles/PMC1851853/ /pubmed/17255324 http://dx.doi.org/10.2353/ajpath.2007.060893 Text en Copyright © American Society for Investigative Pathology |
spellingShingle | Regular Articles Burrer, Renaud Buchmeier, Michael J. Wolfe, Tom Ting, Joey P.C. Feuer, Ralph Iglesias, Antonio von Herrath, Matthias G. Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies |
title | Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies |
title_full | Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies |
title_fullStr | Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies |
title_full_unstemmed | Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies |
title_short | Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies |
title_sort | exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies |
topic | Regular Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851853/ https://www.ncbi.nlm.nih.gov/pubmed/17255324 http://dx.doi.org/10.2353/ajpath.2007.060893 |
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