Metastatic duodenal GIST: role of surgery combined with imatinib mesylate

BACKGROUND: The best possible treatment of metastatic high grade large duodenal GIST is controversial. Surgery (with or without segmental organ resection) remains the principal treatment for primary and recurrent GIST. However, patients with advanced duodenal GIST have a high risk of early tumour re...

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Autores principales: Mohiuddin, Kamran, Nizami, Saira, Munir, Asma, Memon, Breda, Memon, Muhammed A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851968/
https://www.ncbi.nlm.nih.gov/pubmed/17391535
http://dx.doi.org/10.1186/1477-7800-4-9
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author Mohiuddin, Kamran
Nizami, Saira
Munir, Asma
Memon, Breda
Memon, Muhammed A
author_facet Mohiuddin, Kamran
Nizami, Saira
Munir, Asma
Memon, Breda
Memon, Muhammed A
author_sort Mohiuddin, Kamran
collection PubMed
description BACKGROUND: The best possible treatment of metastatic high grade large duodenal GIST is controversial. Surgery (with or without segmental organ resection) remains the principal treatment for primary and recurrent GIST. However, patients with advanced duodenal GIST have a high risk of early tumour recurrence and short life expectancy. METHOD: We present a case of a young man treated with a combined modality of surgery and imatinib for an advanced duodenal GIST. RESULTS: He remains asymptomatic and disease free 42 months following this combined approach. CONCLUSION: Treatment with imatinib has dramatically improved the outlook for patients with advanced, unresectable and/or metastatic disease.
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spelling pubmed-18519682007-04-13 Metastatic duodenal GIST: role of surgery combined with imatinib mesylate Mohiuddin, Kamran Nizami, Saira Munir, Asma Memon, Breda Memon, Muhammed A Int Semin Surg Oncol Case Report BACKGROUND: The best possible treatment of metastatic high grade large duodenal GIST is controversial. Surgery (with or without segmental organ resection) remains the principal treatment for primary and recurrent GIST. However, patients with advanced duodenal GIST have a high risk of early tumour recurrence and short life expectancy. METHOD: We present a case of a young man treated with a combined modality of surgery and imatinib for an advanced duodenal GIST. RESULTS: He remains asymptomatic and disease free 42 months following this combined approach. CONCLUSION: Treatment with imatinib has dramatically improved the outlook for patients with advanced, unresectable and/or metastatic disease. BioMed Central 2007-03-29 /pmc/articles/PMC1851968/ /pubmed/17391535 http://dx.doi.org/10.1186/1477-7800-4-9 Text en Copyright © 2007 Mohiuddin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mohiuddin, Kamran
Nizami, Saira
Munir, Asma
Memon, Breda
Memon, Muhammed A
Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
title Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
title_full Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
title_fullStr Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
title_full_unstemmed Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
title_short Metastatic duodenal GIST: role of surgery combined with imatinib mesylate
title_sort metastatic duodenal gist: role of surgery combined with imatinib mesylate
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851968/
https://www.ncbi.nlm.nih.gov/pubmed/17391535
http://dx.doi.org/10.1186/1477-7800-4-9
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AT munirasma metastaticduodenalgistroleofsurgerycombinedwithimatinibmesylate
AT memonbreda metastaticduodenalgistroleofsurgerycombinedwithimatinibmesylate
AT memonmuhammeda metastaticduodenalgistroleofsurgerycombinedwithimatinibmesylate

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