Cargando…

Identification of the Endogenous Key Substrates of the Human Organic Cation Transporter OCT2 and Their Implication in Function of Dopaminergic Neurons

BACKGROUND: The etiology of neurodegenerative disorders, such as the accelerated loss of dopaminergic neurons in Parkinson's disease, is unclear. Current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter DAT to contribute to cell death in the dopamine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taubert, Dirk, Grimberg, Gundula, Stenzel, Werner, Schömig, Edgar
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851987/ https://www.ncbi.nlm.nih.gov/pubmed/17460754 http://dx.doi.org/10.1371/journal.pone.0000385

Ejemplares similares

Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates
por: Hacker, Kristina, et al.
Publicado: (2015)

Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
por: Vollmar, Johanna, et al.
Publicado: (2017)

Atypical Substrates of the Organic Cation Transporter 1
por: Redeker, Kyra-Elisa Maria, et al.
Publicado: (2022)

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
por: Nies, Anne T., et al.
Publicado: (2011)

Investigations with Drugs and Pesticides Revealed New Species- and Substrate-Dependent Inhibition by Elacridar and Imazalil in Human and Mouse Organic Cation Transporter OCT2
por: Kuehne, Annett, et al.
Publicado: (2022)

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1
por: Zeng, Yi C., et al.
Publicado: (2023)

Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters
por: Meyer, Marleen Julia, et al.
Publicado: (2022)

Crosstalk of parkin and Ret in dopaminergic neurons
por: Kramer, Edgar R.
Publicado: (2015)

Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior
por: Chohan, Muhammad O., et al.
Publicado: (2022)

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
por: Heise, Michael, et al.
Publicado: (2012)

Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [(11)C]Metoclopramide in Mice
por: Hernández-Lozano, Irene, et al.
Publicado: (2021)

Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2)
por: Maane, Max, et al.
Publicado: (2023)

Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)
por: Ceckova, Martina, et al.
Publicado: (2018)

Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)
por: Sekhar, Gayathri N., et al.
Publicado: (2017)

Oct4-Induced Reprogramming Is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons
por: Deleidi, Michela, et al.
Publicado: (2011)

Effects of 1α,25-dihydroxyvitamin D(3) on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats
por: Vo, Dang-Khoa, et al.
Publicado: (2022)

Substrates of the Human Brain Proton-Organic Cation Antiporter and Comparison with Organic Cation Transporter 1 Activities
por: Doetsch, David A., et al.
Publicado: (2022)

The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
por: Andreev, Emil, et al.
Publicado: (2016)

Organic Cation Transporters (OCTs) in EpiAirway™, a Cellular Model of Normal Human Bronchial Epithelium
por: Barilli, Amelia, et al.
Publicado: (2020)

Pharmacogenetics Meets Metabolomics: Discovery of Tryptophan as a New Endogenous OCT2 Substrate Related to Metformin Disposition
por: Song, Im-Sook, et al.
Publicado: (2012)

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
por: van der Velden, Maarten, et al.
Publicado: (2017)

Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity
por: Lefèvre, Charles R., et al.
Publicado: (2021)

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein
por: Santulli, Chiara, et al.
Publicado: (2022)

Role of the Plasma Membrane Transporter of Organic Cations OCT1 and Its Genetic Variants in Modern Liver Pharmacology
por: Lozano, Elisa, et al.
Publicado: (2013)

Transcription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene
por: Li, Yan, et al.
Publicado: (2016)

Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)
por: Bokelmann, Kristin, et al.
Publicado: (2018)

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
por: Chen, Eugene C., et al.
Publicado: (2022)

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice
por: Wang, Qingshan, et al.
Publicado: (2012)

Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3
por: Gebauer, Lukas, et al.
Publicado: (2021)

Evidence for dopaminergic involvement in endogenous modulation of pain relief
por: Desch, Simon, et al.
Publicado: (2023)

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
por: Seitz, Tina, et al.
Publicado: (2015)

Organic Cation Transporter 1 (OCT1) mRNA expression in hepatocellular carcinoma as a biomarker for sorafenib treatment
por: Grimm, Daniel, et al.
Publicado: (2016)

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content
por: Liang, Xiaomin, et al.
Publicado: (2018)

Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models
por: Haberkorn, Bastian, et al.
Publicado: (2021)

The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation
por: Rabe, Tamara I, et al.
Publicado: (2012)

Disinhibition Bursting of Dopaminergic Neurons
por: Lobb, Collin J., et al.
Publicado: (2011)

Parkinson's disease and dopaminergic neurons
Publicado: (2012)

Decreased NAD+ in dopaminergic neurons
por: Sison, Samantha L., et al.
Publicado: (2018)

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
por: Schaeffeler, Elke, et al.
Publicado: (2011)

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice
por: Li, Shuanglian, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_rac27vcgtdegjaf44utae0gr0q