Cargando…
Identification of the Endogenous Key Substrates of the Human Organic Cation Transporter OCT2 and Their Implication in Function of Dopaminergic Neurons
BACKGROUND: The etiology of neurodegenerative disorders, such as the accelerated loss of dopaminergic neurons in Parkinson's disease, is unclear. Current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter DAT to contribute to cell death in the dopamine...
Autores principales: | Taubert, Dirk, Grimberg, Gundula, Stenzel, Werner, Schömig, Edgar |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851987/ https://www.ncbi.nlm.nih.gov/pubmed/17460754 http://dx.doi.org/10.1371/journal.pone.0000385 |
Ejemplares similares
-
Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates
por: Hacker, Kristina, et al.
Publicado: (2015) -
Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
por: Vollmar, Johanna, et al.
Publicado: (2017) -
Atypical Substrates of the Organic Cation Transporter 1
por: Redeker, Kyra-Elisa Maria, et al.
Publicado: (2022) -
Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
por: Nies, Anne T., et al.
Publicado: (2011) -
Investigations with Drugs and Pesticides Revealed New Species- and Substrate-Dependent Inhibition by Elacridar and Imazalil in Human and Mouse Organic Cation Transporter OCT2
por: Kuehne, Annett, et al.
Publicado: (2022)