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A persistent mitochondrial deletion reduces fitness and sperm performance in heteroplasmic populations of C. elegans

BACKGROUND: Mitochondrial DNA (mtDNA) mutations are of increasing interest due to their involvement in aging, disease, fertility, and their role in the evolution of the mitochondrial genome. The presence of reactive oxygen species and the near lack of repair mechanisms cause mtDNA to mutate at a fas...

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Detalles Bibliográficos
Autores principales:	Liau, Wei-Siang, Gonzalez-Serricchio, Aidyl S, Deshommes, Cleonique, Chin, Kara, LaMunyon, Craig W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852114/ https://www.ncbi.nlm.nih.gov/pubmed/17394659 http://dx.doi.org/10.1186/1471-2156-8-8

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