A mathematical model separates quantitatively the cytostatic and cytotoxic effects of a HER2 tyrosine kinase inhibitor

BACKGROUND: Oncogene signaling is known to deregulate cell proliferation resulting in uncontrolled growth and cellular transformation. Gene amplification and/or somatic mutations of the HER2/Neu (ErbB2) proto-oncogene occur in approximately 20% of breast cancers. A therapeutic strategy that has been...

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Detalles Bibliográficos
Autores principales: Hinow, Peter, Wang, Shizhen Emily, Arteaga, Carlos L, Webb, Glenn F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852549/
https://www.ncbi.nlm.nih.gov/pubmed/17407594
http://dx.doi.org/10.1186/1742-4682-4-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852549/
https://www.ncbi.nlm.nih.gov/pubmed/17407594
http://dx.doi.org/10.1186/1742-4682-4-14

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