Cargando…

The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects

BACKGROUND: Foods enriched with phytosterols have been proven to be an effective therapy to improve blood lipid profiles. However, none of the studies have investigated the efficacy in lipid lowering of plant sterol esters (PSE) in capsule form. The objective of this study is to determine if the pla...

Descripción completa

Detalles Bibliográficos
Autores principales: Acuff, Robert V, Cai, David J, Dong, Zhi-Ping, Bell, Doris
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852556/
https://www.ncbi.nlm.nih.gov/pubmed/17419879
http://dx.doi.org/10.1186/1476-511X-6-11
_version_ 1782133059027468288
author Acuff, Robert V
Cai, David J
Dong, Zhi-Ping
Bell, Doris
author_facet Acuff, Robert V
Cai, David J
Dong, Zhi-Ping
Bell, Doris
author_sort Acuff, Robert V
collection PubMed
description BACKGROUND: Foods enriched with phytosterols have been proven to be an effective therapy to improve blood lipid profiles. However, none of the studies have investigated the efficacy in lipid lowering of plant sterol esters (PSE) in capsule form. The objective of this study is to determine if the plant sterol esters (PSE) in capsule form (1.3 grams of PSE/day) lowered plasma cholesterol levels and lipid ratios in free-living hypercholesterolemic subjects during a 4-week intervention period. METHODS: Sixteen subjects participated in a double-blind, placebo-controlled, sequential study with a 4-week placebo phase followed by a 2-week wash-out period and a 4-week treatment phase. Subjects were instructed to maintain stable diet pattern and physical activities. Blood samples were collected at 7, 21 and 28 days of each phase. The primary measurements were change in plasma total cholesterol (TC), HDL-cholesterol (HDL) and LDL-cholesterol (LDL) between phases and within each phase. The secondary measurements were change in triglycerides, lipoprotein ratios (TC/HDL, LDL/HDL) and C-reactive protein (CRP). RESULTS: In comparison to placebo, LDL-cholesterol was significantly reduced by 7% and 4% (P < 0.05) at both week 3 and week 4; HDL at week 3 of the treatment was significantly increased by 9% (P < 0.01), but not at week 4 (4%); total cholesterol was not significantly different from placebo throughout the period, TC/HDL and LDL/HDL were significantly reduced by (8%, 8%, 6%, 10%, respectively) (P < 0.01) at both week 3 and week 4. CRP and triglycerides did not differ either between the two phases or during the treatment phase. CONCLUSION: In conclusion, plant sterol ester capsule is effective in improving lipid profiles among hypercholesterolemic subjects in a free-living setting at the minimum dosage recommended by FDA. The significant improved lipid profiles were reached after three weeks of administration. To achieve better lipid lowering results, higher dosages and combination with diets low in saturated fat and cholesterol are recommended.
format Text
id pubmed-1852556
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-18525562007-04-18 The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects Acuff, Robert V Cai, David J Dong, Zhi-Ping Bell, Doris Lipids Health Dis Research BACKGROUND: Foods enriched with phytosterols have been proven to be an effective therapy to improve blood lipid profiles. However, none of the studies have investigated the efficacy in lipid lowering of plant sterol esters (PSE) in capsule form. The objective of this study is to determine if the plant sterol esters (PSE) in capsule form (1.3 grams of PSE/day) lowered plasma cholesterol levels and lipid ratios in free-living hypercholesterolemic subjects during a 4-week intervention period. METHODS: Sixteen subjects participated in a double-blind, placebo-controlled, sequential study with a 4-week placebo phase followed by a 2-week wash-out period and a 4-week treatment phase. Subjects were instructed to maintain stable diet pattern and physical activities. Blood samples were collected at 7, 21 and 28 days of each phase. The primary measurements were change in plasma total cholesterol (TC), HDL-cholesterol (HDL) and LDL-cholesterol (LDL) between phases and within each phase. The secondary measurements were change in triglycerides, lipoprotein ratios (TC/HDL, LDL/HDL) and C-reactive protein (CRP). RESULTS: In comparison to placebo, LDL-cholesterol was significantly reduced by 7% and 4% (P < 0.05) at both week 3 and week 4; HDL at week 3 of the treatment was significantly increased by 9% (P < 0.01), but not at week 4 (4%); total cholesterol was not significantly different from placebo throughout the period, TC/HDL and LDL/HDL were significantly reduced by (8%, 8%, 6%, 10%, respectively) (P < 0.01) at both week 3 and week 4. CRP and triglycerides did not differ either between the two phases or during the treatment phase. CONCLUSION: In conclusion, plant sterol ester capsule is effective in improving lipid profiles among hypercholesterolemic subjects in a free-living setting at the minimum dosage recommended by FDA. The significant improved lipid profiles were reached after three weeks of administration. To achieve better lipid lowering results, higher dosages and combination with diets low in saturated fat and cholesterol are recommended. BioMed Central 2007-04-09 /pmc/articles/PMC1852556/ /pubmed/17419879 http://dx.doi.org/10.1186/1476-511X-6-11 Text en Copyright © 2007 Acuff et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Acuff, Robert V
Cai, David J
Dong, Zhi-Ping
Bell, Doris
The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
title The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
title_full The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
title_fullStr The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
title_full_unstemmed The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
title_short The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
title_sort lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852556/
https://www.ncbi.nlm.nih.gov/pubmed/17419879
http://dx.doi.org/10.1186/1476-511X-6-11
work_keys_str_mv AT acuffrobertv thelipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT caidavidj thelipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT dongzhiping thelipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT belldoris thelipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT acuffrobertv lipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT caidavidj lipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT dongzhiping lipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects
AT belldoris lipidloweringeffectofplantsterolestercapsulesinhypercholesterolemicsubjects