The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3

BACKGROUND: SH3 domains are small protein modules of 60–85 amino acids that bind to short proline-rich sequences with moderate-to-low affinity and specificity. Interactions with SH3 domains play a crucial role in regulation of many cellular processes (some are related to cancer and AIDS) and have th...

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Detalles Bibliográficos
Autores principales: Casares, Salvador, AB, Eiso, Eshuis, Henk, Lopez-Mayorga, Obdulio, van Nuland, Nico AJ, Conejero-Lara, Francisco
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853097/
https://www.ncbi.nlm.nih.gov/pubmed/17407569
http://dx.doi.org/10.1186/1472-6807-7-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853097/
https://www.ncbi.nlm.nih.gov/pubmed/17407569
http://dx.doi.org/10.1186/1472-6807-7-22

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