A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII

BACKGROUND: Mutations of the epidermal growth factor receptor (EGFR) are a possible molecular target for cancer therapy. EGFR is frequently amplified in glioblastomas and 30 to 40% of glioblastomas also express the deletion mutation EGFRvIII. This frequent oncogenic mutation provides an opportunity...

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Detalles Bibliográficos
Autores principales: Trembath, Dimitri G, Lal, Anita, Kroll, David J, Oberlies, Nicholas H, Riggins, Gregory J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855066/
https://www.ncbi.nlm.nih.gov/pubmed/17437646
http://dx.doi.org/10.1186/1476-4598-6-30

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