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PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle
BACKGROUND: Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857697/ https://www.ncbi.nlm.nih.gov/pubmed/17437640 http://dx.doi.org/10.1186/1471-2156-8-15 |
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author | Haase, Bianca Doherr, Marcus G Seuberlich, Torsten Drögemüller, Cord Dolf, Gaudenz Nicken, Petra Schiebel, Katrin Ziegler, Ute Groschup, Martin H Zurbriggen, Andreas Leeb, Tosso |
author_facet | Haase, Bianca Doherr, Marcus G Seuberlich, Torsten Drögemüller, Cord Dolf, Gaudenz Nicken, Petra Schiebel, Katrin Ziegler, Ute Groschup, Martin H Zurbriggen, Andreas Leeb, Tosso |
author_sort | Haase, Bianca |
collection | PubMed |
description | BACKGROUND: Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a major influence on susceptibility to bovine spongiform encephalopathy (BSE). Recently, however, we demonstrated an association between susceptibility to BSE and a 23 bp insertion/deletion (indel) polymorphism and a 12 bp indel polymorphism within the putative PRNP promoter region using 43 German BSE cases and 48 German control cattle. The objective of this study was to extend this work by including a larger number of BSE cases and control cattle of German and Swiss origin. RESULTS: Allele, genotype and haplotype frequencies of the two indel polymorphisms were determined in 449 BSE cattle and 431 unaffected cattle from Switzerland and Germany including all 43 German BSE and 16 German control animals from the original study. When breeds with similar allele and genotype distributions were compared, the 23 bp indel polymorphism again showed a significant association with susceptibility to BSE. However, some additional breed-specific allele and genotype distributions were identified, mainly related to the Brown breeds. CONCLUSION: Our study corroborated earlier findings that polymorphisms in the PRNP promoter region have an influence on susceptibility to BSE. However, breed-specific differences exist that need to be accounted for when analyzing such data. |
format | Text |
id | pubmed-1857697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18576972007-04-27 PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle Haase, Bianca Doherr, Marcus G Seuberlich, Torsten Drögemüller, Cord Dolf, Gaudenz Nicken, Petra Schiebel, Katrin Ziegler, Ute Groschup, Martin H Zurbriggen, Andreas Leeb, Tosso BMC Genet Research Article BACKGROUND: Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans. In cattle, none of the known polymorphisms within the PRNP coding region has a major influence on susceptibility to bovine spongiform encephalopathy (BSE). Recently, however, we demonstrated an association between susceptibility to BSE and a 23 bp insertion/deletion (indel) polymorphism and a 12 bp indel polymorphism within the putative PRNP promoter region using 43 German BSE cases and 48 German control cattle. The objective of this study was to extend this work by including a larger number of BSE cases and control cattle of German and Swiss origin. RESULTS: Allele, genotype and haplotype frequencies of the two indel polymorphisms were determined in 449 BSE cattle and 431 unaffected cattle from Switzerland and Germany including all 43 German BSE and 16 German control animals from the original study. When breeds with similar allele and genotype distributions were compared, the 23 bp indel polymorphism again showed a significant association with susceptibility to BSE. However, some additional breed-specific allele and genotype distributions were identified, mainly related to the Brown breeds. CONCLUSION: Our study corroborated earlier findings that polymorphisms in the PRNP promoter region have an influence on susceptibility to BSE. However, breed-specific differences exist that need to be accounted for when analyzing such data. BioMed Central 2007-04-16 /pmc/articles/PMC1857697/ /pubmed/17437640 http://dx.doi.org/10.1186/1471-2156-8-15 Text en Copyright © 2007 Haase et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Haase, Bianca Doherr, Marcus G Seuberlich, Torsten Drögemüller, Cord Dolf, Gaudenz Nicken, Petra Schiebel, Katrin Ziegler, Ute Groschup, Martin H Zurbriggen, Andreas Leeb, Tosso PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle |
title | PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle |
title_full | PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle |
title_fullStr | PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle |
title_full_unstemmed | PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle |
title_short | PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle |
title_sort | prnp promoter polymorphisms are associated with bse susceptibility in swiss and german cattle |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857697/ https://www.ncbi.nlm.nih.gov/pubmed/17437640 http://dx.doi.org/10.1186/1471-2156-8-15 |
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