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Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?

Lifespan can be extended by reduction of dietary intake. This practice is referred to as dietary restriction (DR), and extension of lifespan by DR is evolutionarily conserved in taxonomically diverse organisms including yeast, invertebrates, and mammals. Although these two often-stated facts carry t...

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Detalles Bibliográficos
Autores principales: Piper, Matthew D. W, Partridge, Linda
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857724/
https://www.ncbi.nlm.nih.gov/pubmed/17465680
http://dx.doi.org/10.1371/journal.pgen.0030057
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author Piper, Matthew D. W
Partridge, Linda
author_facet Piper, Matthew D. W
Partridge, Linda
author_sort Piper, Matthew D. W
collection PubMed
description Lifespan can be extended by reduction of dietary intake. This practice is referred to as dietary restriction (DR), and extension of lifespan by DR is evolutionarily conserved in taxonomically diverse organisms including yeast, invertebrates, and mammals. Although these two often-stated facts carry the implication that the mechanisms of DR are also evolutionarily conserved, extension of lifespan could be a case of evolutionary convergence, with different underlying mechanisms in different taxa. Furthermore, extension of lifespan by different methods of DR in the same organism may operate through different mechanisms. These topics remain unresolved because of the very fact that the mechanisms of DR are unknown. Given these uncertainties, it is essential that work on the mechanisms of DR is not clouded by imprecise descriptions of methods or by technical problems. Here we review the recent literature on DR in Drosophila to point out some methodological issues that can obscure mechanistic interpretations. We also indicate some experiments that could be performed to determine if DR in Drosophila operates through similar mechanisms to the process in rodents.
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spelling pubmed-18577242007-04-27 Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact? Piper, Matthew D. W Partridge, Linda PLoS Genet Review Lifespan can be extended by reduction of dietary intake. This practice is referred to as dietary restriction (DR), and extension of lifespan by DR is evolutionarily conserved in taxonomically diverse organisms including yeast, invertebrates, and mammals. Although these two often-stated facts carry the implication that the mechanisms of DR are also evolutionarily conserved, extension of lifespan could be a case of evolutionary convergence, with different underlying mechanisms in different taxa. Furthermore, extension of lifespan by different methods of DR in the same organism may operate through different mechanisms. These topics remain unresolved because of the very fact that the mechanisms of DR are unknown. Given these uncertainties, it is essential that work on the mechanisms of DR is not clouded by imprecise descriptions of methods or by technical problems. Here we review the recent literature on DR in Drosophila to point out some methodological issues that can obscure mechanistic interpretations. We also indicate some experiments that could be performed to determine if DR in Drosophila operates through similar mechanisms to the process in rodents. Public Library of Science 2007-04 2007-04-27 /pmc/articles/PMC1857724/ /pubmed/17465680 http://dx.doi.org/10.1371/journal.pgen.0030057 Text en © 2007 Piper and Partridge. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Piper, Matthew D. W
Partridge, Linda
Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
title Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
title_full Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
title_fullStr Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
title_full_unstemmed Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
title_short Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?
title_sort dietary restriction in drosophila: delayed aging or experimental artefact?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857724/
https://www.ncbi.nlm.nih.gov/pubmed/17465680
http://dx.doi.org/10.1371/journal.pgen.0030057
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