Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments. The replicative lifespan of primary human cells is telomere dependent; however, its heterogeneity is not understood. We show that mitoch...

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Detalles Bibliográficos
Autores principales: Passos, João F, Saretzki, Gabriele, Ahmed, Shaheda, Nelson, Glyn, Richter, Torsten, Peters, Heiko, Wappler, Ilka, Birket, Matthew J, Harold, Graham, Schaeuble, Karin, Birch-Machin, Mark A, Kirkwood, Thomas B. L, von Zglinicki, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858712/
https://www.ncbi.nlm.nih.gov/pubmed/17472436
http://dx.doi.org/10.1371/journal.pbio.0050110

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