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MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics

We developed a novel method for identifying SNPs widely distributed throughout the coding and non-coding regions of a genome. The method uses large-scale parallel pyrosequencing technology in combination with bioinformatics tools. We used this method to generate approximately 23,000 candidate SNPs t...

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Detalles Bibliográficos
Autores principales: Malhi, Ripan S., Sickler, Brad, Lin, Dawei, Satkoski, Jessica, Tito, Raul Y., George, Debbie, Kanthaswamy, Sreetharan, Smith, David Glenn
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859839/
https://www.ncbi.nlm.nih.gov/pubmed/17487284
http://dx.doi.org/10.1371/journal.pone.0000438
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author Malhi, Ripan S.
Sickler, Brad
Lin, Dawei
Satkoski, Jessica
Tito, Raul Y.
George, Debbie
Kanthaswamy, Sreetharan
Smith, David Glenn
author_facet Malhi, Ripan S.
Sickler, Brad
Lin, Dawei
Satkoski, Jessica
Tito, Raul Y.
George, Debbie
Kanthaswamy, Sreetharan
Smith, David Glenn
author_sort Malhi, Ripan S.
collection PubMed
description We developed a novel method for identifying SNPs widely distributed throughout the coding and non-coding regions of a genome. The method uses large-scale parallel pyrosequencing technology in combination with bioinformatics tools. We used this method to generate approximately 23,000 candidate SNPs throughout the Macaca mulatta genome. We estimate that over 60% of the SNPs will be of high frequency and useful for mapping QTLs, genetic management, and studies of individual relatedness, whereas other less frequent SNPs may be useful as population specific markers for ancestry identification. We have created a web resource called MamuSNP to view the SNPs and associated information online. This resource will also be useful for researchers using a wide variety of Macaca species in their research.
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spelling pubmed-18598392007-05-09 MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics Malhi, Ripan S. Sickler, Brad Lin, Dawei Satkoski, Jessica Tito, Raul Y. George, Debbie Kanthaswamy, Sreetharan Smith, David Glenn PLoS One Research Article We developed a novel method for identifying SNPs widely distributed throughout the coding and non-coding regions of a genome. The method uses large-scale parallel pyrosequencing technology in combination with bioinformatics tools. We used this method to generate approximately 23,000 candidate SNPs throughout the Macaca mulatta genome. We estimate that over 60% of the SNPs will be of high frequency and useful for mapping QTLs, genetic management, and studies of individual relatedness, whereas other less frequent SNPs may be useful as population specific markers for ancestry identification. We have created a web resource called MamuSNP to view the SNPs and associated information online. This resource will also be useful for researchers using a wide variety of Macaca species in their research. Public Library of Science 2007-05-09 /pmc/articles/PMC1859839/ /pubmed/17487284 http://dx.doi.org/10.1371/journal.pone.0000438 Text en Malhi et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Malhi, Ripan S.
Sickler, Brad
Lin, Dawei
Satkoski, Jessica
Tito, Raul Y.
George, Debbie
Kanthaswamy, Sreetharan
Smith, David Glenn
MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics
title MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics
title_full MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics
title_fullStr MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics
title_full_unstemmed MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics
title_short MamuSNP: A Resource for Rhesus Macaque (Macaca mulatta) Genomics
title_sort mamusnp: a resource for rhesus macaque (macaca mulatta) genomics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859839/
https://www.ncbi.nlm.nih.gov/pubmed/17487284
http://dx.doi.org/10.1371/journal.pone.0000438
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