Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation

Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses...

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Detalles Bibliográficos
Autores principales: Kolf, Catherine M, Cho, Elizabeth, Tuan, Rocky S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860068/
https://www.ncbi.nlm.nih.gov/pubmed/17316462
http://dx.doi.org/10.1186/ar2116
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author Kolf, Catherine M
Cho, Elizabeth
Tuan, Rocky S
author_facet Kolf, Catherine M
Cho, Elizabeth
Tuan, Rocky S
author_sort Kolf, Catherine M
collection PubMed
description Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.
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spelling pubmed-18600682007-05-02 Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation Kolf, Catherine M Cho, Elizabeth Tuan, Rocky S Arthritis Res Ther Review Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells. BioMed Central 2007 2007-02-19 /pmc/articles/PMC1860068/ /pubmed/17316462 http://dx.doi.org/10.1186/ar2116 Text en Copyright © 2007 BioMed Central Ltd
spellingShingle Review
Kolf, Catherine M
Cho, Elizabeth
Tuan, Rocky S
Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
title Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
title_full Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
title_fullStr Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
title_full_unstemmed Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
title_short Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
title_sort mesenchymal stromal cells. biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860068/
https://www.ncbi.nlm.nih.gov/pubmed/17316462
http://dx.doi.org/10.1186/ar2116
work_keys_str_mv AT kolfcatherinem mesenchymalstromalcellsbiologyofadultmesenchymalstemcellsregulationofnicheselfrenewalanddifferentiation
AT choelizabeth mesenchymalstromalcellsbiologyofadultmesenchymalstemcellsregulationofnicheselfrenewalanddifferentiation
AT tuanrockys mesenchymalstromalcellsbiologyofadultmesenchymalstemcellsregulationofnicheselfrenewalanddifferentiation

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