LRP1 Functions as an Atheroprotective Integrator of TGFβ and PDGF Signals in the Vascular Wall: Implications for Marfan Syndrome

BACKGROUND: The multifunctional receptor LRP1 controls expression, activity and trafficking of the PDGF receptor-β in vascular smooth muscle cells (VSMC). LRP1 is also a receptor for TGFβ1 and is required for TGFβ mediated inhibition of cell proliferation. METHODS AND PRINCIPAL FINDINGS: We show tha...

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Detalles Bibliográficos
Autores principales: Boucher, Philippe, Li, Wei-Ping, Matz, Rachel L., Takayama, Yoshiharu, Auwerx, Johan, Anderson, Richard G.W., Herz, Joachim
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864997/
https://www.ncbi.nlm.nih.gov/pubmed/17505534
http://dx.doi.org/10.1371/journal.pone.0000448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864997/
https://www.ncbi.nlm.nih.gov/pubmed/17505534
http://dx.doi.org/10.1371/journal.pone.0000448

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