Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques

Cre is widely used for DNA tailoring and, in combination with recombineering techniques, to modify BAC/PAC sequences for generating transgenic animals. However, mammalian genomes contain recombinase recognition sites (cryptic loxP sites) that can promote illegitimate DNA recombination and damage whe...

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Detalles Bibliográficos
Autores principales: Semprini, S., Troup, T.J., Kotelevtseva, N., King, K., Davis, J.R.E., Mullins, L.J., Chapman, K.E., Dunbar, D.R., Mullins, J.J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865043/
https://www.ncbi.nlm.nih.gov/pubmed/17284462
http://dx.doi.org/10.1093/nar/gkl1108

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