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Insights into Fanconi Anaemia from the structure of human FANCE

Fanconi Anaemia (FA) is a cancer predisposition disorder characterized by spontaneous chromosome breakage and high cellular sensitivity to genotoxic agents. In response to DNA damage, a multi-subunit assembly of FA proteins, the FA core complex, monoubiquitinates the downstream FANCD2 protein. The F...

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Detalles Bibliográficos
Autores principales:	Nookala, Ravi K., Hussain, Shobbir, Pellegrini, Luca
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865054/ https://www.ncbi.nlm.nih.gov/pubmed/17308347 http://dx.doi.org/10.1093/nar/gkm033

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