Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration

Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involving mutant Htt. We therefore hypothesized that...

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Detalles Bibliográficos
Autores principales: Kaltenbach, Linda S, Romero, Eliana, Becklin, Robert R, Chettier, Rakesh, Bell, Russell, Phansalkar, Amit, Strand, Andrew, Torcassi, Cameron, Savage, Justin, Hurlburt, Anthony, Cha, Guang-Ho, Ukani, Lubna, Chepanoske, Cindy Lou, Zhen, Yuejun, Sahasrabudhe, Sudhir, Olson, James, Kurschner, Cornelia, Ellerby, Lisa M, Peltier, John M, Botas, Juan, Hughes, Robert E
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866352/
https://www.ncbi.nlm.nih.gov/pubmed/17500595
http://dx.doi.org/10.1371/journal.pgen.0030082

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