Search for genetic factors predisposing to atherogenic dyslipidemia

BACKGROUND: Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have investigated the AD lipid triad comprising elevated serum triglyceride, small...

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Detalles Bibliográficos
Autores principales: Yip, Agustin G, Ma, Qianli, Wilcox, Marsha, Panhuysen, Carolien I, Farrell, John, Farrer, Lindsay A, Wyszynski, Diego F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866438/
https://www.ncbi.nlm.nih.gov/pubmed/14975168
http://dx.doi.org/10.1186/1471-2156-4-S1-S100
Descripción
Sumario:BACKGROUND: Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have investigated the AD lipid triad comprising elevated serum triglyceride, small low density lipoprotein (LDL) particles, and reduced high density lipoprotein (HDL) cholesterol levels. Here we report the results of a whole-genome screen for AD using the Framingham Heart Study population. RESULTS: Our analyses provide some evidence for linkage to AD on chromosomes 1q31, 3q29, 10q26, 14p12, 14q13, 16q24, 18p11, and 19q13. CONCLUSION: AD susceptibility is modulated by multiple genes in different chromosomes. Our study confirms results from other populations and suggests new areas of potential importance.

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