Search for genetic factors predisposing to atherogenic dyslipidemia

BACKGROUND: Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have investigated the AD lipid triad comprising elevated serum triglyceride, small...

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Autores principales: Yip, Agustin G, Ma, Qianli, Wilcox, Marsha, Panhuysen, Carolien I, Farrell, John, Farrer, Lindsay A, Wyszynski, Diego F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866438/
https://www.ncbi.nlm.nih.gov/pubmed/14975168
http://dx.doi.org/10.1186/1471-2156-4-S1-S100
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author Yip, Agustin G
Ma, Qianli
Wilcox, Marsha
Panhuysen, Carolien I
Farrell, John
Farrer, Lindsay A
Wyszynski, Diego F
author_facet Yip, Agustin G
Ma, Qianli
Wilcox, Marsha
Panhuysen, Carolien I
Farrell, John
Farrer, Lindsay A
Wyszynski, Diego F
author_sort Yip, Agustin G
collection PubMed
description BACKGROUND: Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have investigated the AD lipid triad comprising elevated serum triglyceride, small low density lipoprotein (LDL) particles, and reduced high density lipoprotein (HDL) cholesterol levels. Here we report the results of a whole-genome screen for AD using the Framingham Heart Study population. RESULTS: Our analyses provide some evidence for linkage to AD on chromosomes 1q31, 3q29, 10q26, 14p12, 14q13, 16q24, 18p11, and 19q13. CONCLUSION: AD susceptibility is modulated by multiple genes in different chromosomes. Our study confirms results from other populations and suggests new areas of potential importance.
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spelling pubmed-18664382007-05-11 Search for genetic factors predisposing to atherogenic dyslipidemia Yip, Agustin G Ma, Qianli Wilcox, Marsha Panhuysen, Carolien I Farrell, John Farrer, Lindsay A Wyszynski, Diego F BMC Genet Proceedings BACKGROUND: Atherogenic dyslipidemia (AD) is a common feature in persons with premature coronary heart disease. While several linkage studies have been carried out to dissect the genetic etiology of lipid levels, few have investigated the AD lipid triad comprising elevated serum triglyceride, small low density lipoprotein (LDL) particles, and reduced high density lipoprotein (HDL) cholesterol levels. Here we report the results of a whole-genome screen for AD using the Framingham Heart Study population. RESULTS: Our analyses provide some evidence for linkage to AD on chromosomes 1q31, 3q29, 10q26, 14p12, 14q13, 16q24, 18p11, and 19q13. CONCLUSION: AD susceptibility is modulated by multiple genes in different chromosomes. Our study confirms results from other populations and suggests new areas of potential importance. BioMed Central 2003-12-31 /pmc/articles/PMC1866438/ /pubmed/14975168 http://dx.doi.org/10.1186/1471-2156-4-S1-S100 Text en Copyright © 2003 Yip et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Yip, Agustin G
Ma, Qianli
Wilcox, Marsha
Panhuysen, Carolien I
Farrell, John
Farrer, Lindsay A
Wyszynski, Diego F
Search for genetic factors predisposing to atherogenic dyslipidemia
title Search for genetic factors predisposing to atherogenic dyslipidemia
title_full Search for genetic factors predisposing to atherogenic dyslipidemia
title_fullStr Search for genetic factors predisposing to atherogenic dyslipidemia
title_full_unstemmed Search for genetic factors predisposing to atherogenic dyslipidemia
title_short Search for genetic factors predisposing to atherogenic dyslipidemia
title_sort search for genetic factors predisposing to atherogenic dyslipidemia
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866438/
https://www.ncbi.nlm.nih.gov/pubmed/14975168
http://dx.doi.org/10.1186/1471-2156-4-S1-S100
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