Genome-wide screen for heavy alcohol consumption

BACKGROUND: To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected by the Framingham Heart Study made available to participants in the Genetic An...

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Autores principales: Wyszynski, Diego F, Panhuysen, Carolien I, Ma, Qianli, Yip, Agustin G, Wilcox, Marsha, Erlich, Porat, Farrer, Lindsay A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866444/
https://www.ncbi.nlm.nih.gov/pubmed/14975174
http://dx.doi.org/10.1186/1471-2156-4-S1-S106
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author Wyszynski, Diego F
Panhuysen, Carolien I
Ma, Qianli
Yip, Agustin G
Wilcox, Marsha
Erlich, Porat
Farrer, Lindsay A
author_facet Wyszynski, Diego F
Panhuysen, Carolien I
Ma, Qianli
Yip, Agustin G
Wilcox, Marsha
Erlich, Porat
Farrer, Lindsay A
author_sort Wyszynski, Diego F
collection PubMed
description BACKGROUND: To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected by the Framingham Heart Study made available to participants in the Genetic Analysis Workshop 13 (GAW13). RESULTS: Parametric and nonparametric methods of linkage analysis were used. No significant evidence of linkage was found; however, weak signals were identified in several chromosomal regions, including 1p22, 4q12, 4q25, and 11q24, which are in the vicinity of those reported in other similar studies. CONCLUSION: Our study did not reveal significant evidence of linkage to heavy alcohol use; however, we found weak confirmation of studies carried out in other populations.
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spelling pubmed-18664442007-05-11 Genome-wide screen for heavy alcohol consumption Wyszynski, Diego F Panhuysen, Carolien I Ma, Qianli Yip, Agustin G Wilcox, Marsha Erlich, Porat Farrer, Lindsay A BMC Genet Proceedings BACKGROUND: To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected by the Framingham Heart Study made available to participants in the Genetic Analysis Workshop 13 (GAW13). RESULTS: Parametric and nonparametric methods of linkage analysis were used. No significant evidence of linkage was found; however, weak signals were identified in several chromosomal regions, including 1p22, 4q12, 4q25, and 11q24, which are in the vicinity of those reported in other similar studies. CONCLUSION: Our study did not reveal significant evidence of linkage to heavy alcohol use; however, we found weak confirmation of studies carried out in other populations. BioMed Central 2003-12-31 /pmc/articles/PMC1866444/ /pubmed/14975174 http://dx.doi.org/10.1186/1471-2156-4-S1-S106 Text en Copyright © 2003 Wyszynski et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Wyszynski, Diego F
Panhuysen, Carolien I
Ma, Qianli
Yip, Agustin G
Wilcox, Marsha
Erlich, Porat
Farrer, Lindsay A
Genome-wide screen for heavy alcohol consumption
title Genome-wide screen for heavy alcohol consumption
title_full Genome-wide screen for heavy alcohol consumption
title_fullStr Genome-wide screen for heavy alcohol consumption
title_full_unstemmed Genome-wide screen for heavy alcohol consumption
title_short Genome-wide screen for heavy alcohol consumption
title_sort genome-wide screen for heavy alcohol consumption
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866444/
https://www.ncbi.nlm.nih.gov/pubmed/14975174
http://dx.doi.org/10.1186/1471-2156-4-S1-S106
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