Consistency of linkage results across exams and methods in the Framingham Heart Study

BACKGROUND: The repeated measures in the Framingham Heart Study in the Genetic Analysis Workshop 13 data set allow us to test for consistency of linkage results within a study across time. We compared regression-based linkage to variance components linkage across time for six quantitative traits in...

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Detalles Bibliográficos
Autores principales: Atwood, Larry D, Heard-Costa, Nancy L, Cupples, L Adrienne, Levy, Daniel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866466/
https://www.ncbi.nlm.nih.gov/pubmed/14975098
http://dx.doi.org/10.1186/1471-2156-4-S1-S30
Descripción
Sumario:BACKGROUND: The repeated measures in the Framingham Heart Study in the Genetic Analysis Workshop 13 data set allow us to test for consistency of linkage results within a study across time. We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data. RESULTS: The variance components approach found 11 significant linkages, the regression-based approach found 4. There was only one region that overlapped. Consistency between exams generally decreased as the time interval between exams increased. The regression-based approach showed higher consistency in linkage results across exams. CONCLUSION: The low consistency between exams and between methods may help explain the lack of replication between studies in this field.

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